WEBVTT

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People were told to load Kviatune, and that looks

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like 20 grams a day for about a week. And this

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is to saturate those muscles faster. And technically,

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well, this works. But here's the part that, you

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know, most people may not want to hear. It's

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not necessary, guys. It's not necessary. What's

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up, guys? I'm Jeremiah, a dual board -certified

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NP who has been burned out on traditional insurance

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-based medicine. The solution? Hormones happen.

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This podcast is for you. If you wanna learn the

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truth about hormone replacement therapy, peptides,

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and even direct primary care, join me in talking

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with hundreds of practitioners about what's really

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going on behind the scenes. Welcome back to another

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episode of Hormones Happen. I'm your host, Jeremiah,

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also known as TheOptimizedNP on TikTok. And I

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apologize for those of you who are just listening.

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I did a really cringy bicep flex, okay? But today,

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guys, we're talking about one of the most well

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-studied supplements in the whole world. We're

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talking about creatine monohydrate. Now, to really

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understand creatine... We have to go back in

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time. Let's start with a little history lesson

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about how creatine even came onto the scene.

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So creatine was first identified back in 1832.

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That's when scientists discovered it was inside

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skeletal muscle, like your biceps, your legs.

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Now, even back then, they noticed something pretty

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interesting. When people ate meat, creatine levels

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in their muscles went up. And when muscles work

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harder, Creatine got used faster. Now, fast forward

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to the mids and researchers developed, they uncovered

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what's called phosphocreatine. Now, this is a

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stored form of creatine that helps your cells

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rapidly regenerate what's called adenosine triphosphate

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or ATP. Remember this, this is important. And

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this is basically your body's instant energy

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system. Now, this is what powers short, intense

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efforts. And as we know now, supports brain energy.

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too. Creatine didn't reach mainstream until the

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early 80s when Olympic -level athletes, and some

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of you may know these individuals, such as Linford

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Christie, Sally Gunnell, and Colin Jackson began

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using it. And from there, creatine monohydrate

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became the gold standard because it was effective,

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stable, affordable, and incredibly well -studied.

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In fact, There are roughly 500 to 1 ,000 peer

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-reviewed studies on creatine, most of them creatine

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monohydrate. And here's the key point here. Over

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the last 30 years, creatine has become one of

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the most researched supplements on the planet,

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not just for strength and muscle, but for cognition,

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aging, recovery, and overall cellular energy,

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which is a huge reason why we're talking about

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it today. So while creatine might look like a

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gym supplement, and it's been marketed as one

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for a very long time, On the surface, it's really

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a foundational molecule for overall human performance,

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both physical and mental. The big question is,

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how do you get it? And why should I supplement?

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Well, creatine is found naturally in animal muscle,

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with the highest sources being red meats like

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beef, pork, and bison. But it's also found in

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other meats like fish and chicken as well, just

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in smaller amounts. You might be saying, well,

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I eat tons of meat, Jeremiah. Do I even need

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to supplement with this? And the answer is yes.

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Here's the reality. Even if you eat a lot of

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red meat or fish, most people only get about

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one or two grams of creatine per day from food

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sources. And that's before you factor in cooking,

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which actually destroys some of it. So the research

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shows that to fully saturate your muscles and

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your brain, you typically need three to five

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grams per day. Okay, that's a level most people

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don't reach. through diet alone, unless they're

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eating pounds of meat every single day, which

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some people do. And even then, arguably, you'd

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still benefit. There's also demands to consider

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too. As we age, during periods of stress, intense

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training, poor sleep, even high cognitive load,

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our cells are burning through ATP faster. And

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creatine, as we talked about earlier, helps to

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recycle this ATP. It's like a backup battery

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for both the muscle, and the brain. So supplementation

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isn't about replacing meat. It's about closing

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the gap on what our diet provides and what your

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cells actually use to perform at their best.

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You know why creatine is something you should

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probably look into. How does it work though?

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Well, at the most basic level, creatine helps

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your cells produce energy more quickly. But nobody

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listening to this podcast is basic, so let's

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go deeper, shall we? I want you to think of a

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race car pit crew here, okay? Your muscles run

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on ATP the way that a race car runs on fuel.

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The problem is that ATP depletes quickly, especially

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during heavy lifts, sprints, or explosive movements.

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Creatine acts like a pit crew standing right

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next to the engine. Inside the muscle cells,

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creatine is stored as phosphocreatine like we

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talked about. And when ATP runs low, phosphocreatine

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instantly hands over a phosphate group. And that

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refuels ATP on the spot. No waiting, no delays.

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If mitochondria are the long haul fuel trucks,

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creatine is like a nitrous boost, not for longer

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distance, but for immediate power and recovery

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between your efforts or exercises. Now, supplementing

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creatine increases the size of this pit crew,

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essentially. More phosphocreatine means faster

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ATP refueling, more reps before breakdown, quicker

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recovery between sets. There's also a cell hydration

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effect. Now this is important. Creatine pulls

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water into the muscle cell, making it swell.

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Think of this as inflating a balloon inside the

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muscle. That stretch sends signals that basically

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say we need reinforcement and that promotes muscle

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protein synthesis, and reduces breakdown. With

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that being said, many, not all, will notice some

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weight gain when taking creatine, roughly 1 -3

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pounds after starting. This is a result of increased

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fluid retention in the muscles. This does not

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cause the same kind of swelling you would see

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with conditions like cardiac or kidney disease,

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where you have bloating and puffiness everywhere.

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Rather, it's inside the muscles. And we call

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this intracellular hydration. It's actually a

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good thing. That internal swelling does a couple

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things. It improves leverage and force production.

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It reduces protein breakdown. And it signals

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the muscles that it's in a growth -friendly environment.

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So most researchers consider this water shift

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an anabolic signal, not a side effect. And while

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the effects on muscle are cool, the effects on

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the brain... are cooler. I want you to think

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about creatine as an uninterruptible power supply

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for your neurons. The brain is one of the most

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energy demanding organs in the body, but unlike

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muscle, it has almost no energy storage. It's

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running in real time, all the time. Creatine

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in the brain works like a battery backup system,

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the kind of data centers used to prevent crashes

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when the power flickers, okay? And your neurons,

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they're constantly firing signals. They're maintaining

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ion gradients, releasing neurotransmitters, and

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processing information. All of that costs ATP.

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When energy demands spike during stress, sleep

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deprivation, or mental overload, creatine steps

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in to stabilize the system. Phosphocreatine keeps

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ATP levels steady at the synapse, like a surge

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protector preventing blowouts. Now, instead of

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your brain slowing down or misfiring, it stays

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online now. And we're still using the computer

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analogies here. And that's why creatine has been

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studied for things like mental fatigue, focus

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under stress, mood stability, neural protection,

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cognitive aging. It goes on and on and on. And

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the most important thing about creatine is that

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it's not a stimulant like caffeine. It doesn't

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essentially rev the engine. It just prevents

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those power outages. So even people who are Stimulant

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intolerant can have creatine. Well, how's this

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applied? You've probably seen creatine at GNC

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or a supplement shop and noticed there are several

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different types. Well, let's talk about them

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and which one is best. Which one is the winner

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here? So let's start with creatine ethyl ester.

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The claim on this one is it has better absorption,

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less water retention. Reality breaks down into

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creatine in the gut. It is inferior at raising

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muscle creatine levels. And it's more expensive.

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More expensive, less effective. Who wants that?

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The next one, buffered creatine. Now, the claim

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on this one is it's more stable and less upsetting

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for the stomach. The reality on this one is creatine

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monohydrate is already stable in the stomach.

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Studies show no meaningful performance and advantage.

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And it's really just a marketing solution to

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a non -problem. It's marketing propaganda. Moving

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on to creatine hydrochloride. This one's claim

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is better solubility, smaller doses needed. Well,

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the reality is it dissolves well, but there's

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no strong evidence that it works better. There's

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very few studies that look at this, and it's

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very expensive compared to creatine monohydrate.

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Now, this one's a bit more nuanced. Liquid creatine.

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This one is convenient. That's the claim, right?

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Super convenient. Reality, creatine degrades

00:10:15.799 --> 00:10:18.980
in liquid over time, and it often delivers less

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active creatine than actually advertised. Which

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one wins? Well, we haven't talked about it yet.

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Creatine monohydrate, guys, the gold standard.

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Simply, it's creatine bound to a single water

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molecule. Simple, stable, proven. Now, why does

00:10:35.309 --> 00:10:37.830
this matter? It's the most studied form of creatine

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by a huge margin, consistently increases muscle

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and brain creatine stores, proven benefits for

00:10:43.870 --> 00:10:47.950
strength, power, cognition, aging, and it's safe.

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Not to mention, it's cheap, guys. Cheap, stable,

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well -absorbed. I can go on and on. It's all

00:10:53.470 --> 00:10:55.830
you need and nothing you don't. Probably the

00:10:55.830 --> 00:10:57.730
biggest question I get asked when someone is

00:10:57.730 --> 00:11:04.629
starting for you, Tina, is... I get it. You've

00:11:04.629 --> 00:11:06.529
tried hundreds of supplements in the past with

00:11:06.529 --> 00:11:09.649
disappointing results. Forget it. It ends now.

00:11:09.850 --> 00:11:12.490
At Velasco Supplements, we don't just sell supplements.

00:11:12.730 --> 00:11:15.230
We provide solutions. Having treated thousands

00:11:15.230 --> 00:11:17.950
of men and women with difficulty sleeping, low

00:11:17.950 --> 00:11:20.149
energy, and just not feeling like themselves,

00:11:20.549 --> 00:11:23.169
we've developed these specific formulations based

00:11:23.169 --> 00:11:26.690
on clinical guidelines and science. We've only

00:11:26.690 --> 00:11:28.929
included what works and nothing that doesn't.

00:11:28.929 --> 00:11:31.330
All supplements are third -party tested with

00:11:31.330 --> 00:11:34.200
clear, transparent labeling. Because while I'm

00:11:34.200 --> 00:11:36.460
proud of what's in them, I'm even more proud

00:11:36.460 --> 00:11:39.480
of what's not. It's time to get the results you've

00:11:39.480 --> 00:11:42.600
been waiting for this whole time. Check out velascosupplements

00:11:42.600 --> 00:11:58.419
.com and see if we have a solution for you. Do

00:11:58.419 --> 00:12:01.289
I need to load it? Traditionally... People were

00:12:01.289 --> 00:12:03.370
told to load creatine and that looks like 20

00:12:03.370 --> 00:12:06.169
grams a day for about a week. And this is to

00:12:06.169 --> 00:12:08.789
saturate those muscles faster. And technically,

00:12:09.009 --> 00:12:12.230
well, this works. But here's the part that, you

00:12:12.230 --> 00:12:14.350
know, most people may not want to hear. It's

00:12:14.350 --> 00:12:17.610
not necessary, guys. It's not necessary. I want

00:12:17.610 --> 00:12:19.529
you to think of creatine like filling up a gas

00:12:19.529 --> 00:12:22.450
tank. A loading phase is like dumping fuel in

00:12:22.450 --> 00:12:24.769
there with a fire hose. You fill the tank quickly,

00:12:24.990 --> 00:12:27.929
but anything extra just spills over. A standard

00:12:27.929 --> 00:12:30.490
daily dose is like filling up with a normal pump.

00:12:30.669 --> 00:12:33.409
It takes a little longer, but you end up at the

00:12:33.409 --> 00:12:37.110
same exact result, a full tank of gas. And so

00:12:37.110 --> 00:12:39.289
what does that look like? Typically, you know,

00:12:39.289 --> 00:12:41.809
I recommend five grams a day. Muscle creatine

00:12:41.809 --> 00:12:44.269
stores are still fully saturated. Takes about

00:12:44.269 --> 00:12:46.269
three to four weeks instead of five to seven

00:12:46.269 --> 00:12:48.669
days. And the other thing too is with loading,

00:12:48.850 --> 00:12:51.889
sometimes I'll actually see a backfire because

00:12:51.889 --> 00:12:54.169
aggressive loading increases the amount of creatine

00:12:54.169 --> 00:12:56.269
that's sitting in the gut and the bloodstream

00:12:56.269 --> 00:12:59.139
before the muscles can even absorb it. And a

00:12:59.139 --> 00:13:02.100
lot of people will experience GI upset, bloating,

00:13:02.240 --> 00:13:04.419
cramping. And of course, this is going to be

00:13:04.419 --> 00:13:07.240
that situation where you have much more fluid

00:13:07.240 --> 00:13:09.940
accumulation, rapid water shifts. And so it's

00:13:09.940 --> 00:13:11.779
not that creatine is a problem. It's just that

00:13:11.779 --> 00:13:15.659
the dose exceeds your transport capacity of the

00:13:15.659 --> 00:13:17.460
body in the short term. We have to think long

00:13:17.460 --> 00:13:20.200
term with creatine. When you think creatine,

00:13:20.200 --> 00:13:23.120
think consistency, long term. We can probably

00:13:23.120 --> 00:13:25.899
all agree at this point, at least, that creatine

00:13:25.899 --> 00:13:32.169
is beneficial. The claims of kidney damage, dehydration,

00:13:32.230 --> 00:13:35.049
hair loss. Yeah, let's unpack these myths so

00:13:35.049 --> 00:13:36.950
we can finally move on with our lives, guys.

00:13:37.230 --> 00:13:40.269
Myth 1. Creatine is a steroid. Alright guys,

00:13:40.389 --> 00:13:43.350
the truth is creatine is not a hormone, not synthetic

00:13:43.350 --> 00:13:46.450
testosterone, and it's not an anabolic steroid.

00:13:46.509 --> 00:13:49.450
Creatine is a naturally occurring compound. Like

00:13:49.450 --> 00:13:52.330
I said, found in meat, fish, your own muscle

00:13:52.330 --> 00:13:54.970
cells, and your body already makes one to two

00:13:54.970 --> 00:13:57.970
grams per day. So calling creatine a steroid

00:13:57.970 --> 00:14:00.970
is like calling a protein a drug because it helps

00:14:00.970 --> 00:14:04.309
build muscle. Myth number two, creatine damages

00:14:04.309 --> 00:14:06.870
your kidneys. This myth comes from a lot of confusion

00:14:06.870 --> 00:14:09.629
and not so much evidence. Creatine can slightly

00:14:09.629 --> 00:14:13.049
increase samcreatin, which is a marker of kidney

00:14:13.049 --> 00:14:16.639
function, not kidney damage. And in healthy individuals,

00:14:16.879 --> 00:14:19.240
hundreds of studies have shown no adverse effects

00:14:19.240 --> 00:14:21.580
on kidney function, even with long -term use.

00:14:21.759 --> 00:14:24.700
It's like saying that exercise is dangerous because

00:14:24.700 --> 00:14:27.279
your heart rate goes up during a workout. Now,

00:14:27.320 --> 00:14:29.659
I will put a caveat there is if you have pre

00:14:29.659 --> 00:14:32.120
-existing kidney damage, that could change things

00:14:32.120 --> 00:14:35.600
a little bit. But even so, very safe for the

00:14:35.600 --> 00:14:38.679
kidneys. Myth number three, creatine causes dehydration

00:14:38.679 --> 00:14:41.240
and cramping. Well, as we talked about, the opposite

00:14:41.240 --> 00:14:45.639
is usually true. Creatine increases. intracellular

00:14:45.639 --> 00:14:48.000
hydration remember water inside the muscle cells

00:14:48.000 --> 00:14:51.539
multiple studies show no increased risk of cramps

00:14:51.539 --> 00:14:55.259
or dehydration even in athletes training in the

00:14:55.259 --> 00:14:57.080
heat and the other thing too with the hydration

00:14:57.080 --> 00:14:59.919
is you don't need to excessively hydrate normal

00:14:59.919 --> 00:15:03.179
hydration is completely fine myth number four

00:15:03.179 --> 00:15:05.940
creatine makes you gain fat well we talked about

00:15:05.940 --> 00:15:07.960
the weight gain aspects of this and you know

00:15:08.480 --> 00:15:11.320
The good news is creatine has zero calories and

00:15:11.320 --> 00:15:14.559
does not increase fat mass whatsoever. The early

00:15:14.559 --> 00:15:16.980
weight gain you see, typically one to three pounds,

00:15:17.039 --> 00:15:20.820
is water inside the muscle cells, not fat. And

00:15:20.820 --> 00:15:23.159
over time, in fact, creatine can improve body

00:15:23.159 --> 00:15:26.200
composition by supporting harder training sessions

00:15:26.200 --> 00:15:29.379
and improvement in lean body mass. Myth number

00:15:29.379 --> 00:15:32.279
five, creatine is only for bodybuilders. Well,

00:15:32.379 --> 00:15:34.440
you know, although athletes discovered this,

00:15:34.580 --> 00:15:37.039
everyone can benefit from it. Creatine has been

00:15:37.039 --> 00:15:39.980
studied in women, older adults, vegetarians,

00:15:40.159 --> 00:15:42.960
cognitive and neurological populations. I have

00:15:42.960 --> 00:15:45.759
patients who are 80 years old on creatine and

00:15:45.759 --> 00:15:49.379
they are absolutely thriving. Myth number six,

00:15:49.580 --> 00:15:52.659
creatine causes hair loss. There is no direct

00:15:52.659 --> 00:15:55.720
evidence that creatine causes hair loss. This

00:15:55.720 --> 00:15:58.259
myth comes from a single small study that showed

00:15:58.259 --> 00:16:04.700
a rise in DHT, not actual hair loss. And it hasn't

00:16:04.700 --> 00:16:07.440
been replicated meaningfully since. What is the

00:16:07.440 --> 00:16:09.679
best way to take this? So rounding out this episode,

00:16:09.879 --> 00:16:12.539
I'm going to give you five tips that can help

00:16:12.539 --> 00:16:14.440
you get the most out of your creatine. Number

00:16:14.440 --> 00:16:17.720
one, be consistent. This is the most important.

00:16:17.860 --> 00:16:20.360
This matters more than anything. Creatine works

00:16:20.360 --> 00:16:23.820
by saturating tissues, not acute stimulation.

00:16:24.220 --> 00:16:27.720
Take it every day, even on rest days. This stays.

00:16:28.330 --> 00:16:31.429
Slow that saturation and benefits. Tip number

00:16:31.429 --> 00:16:34.029
two, stick to the right dose. Five grams per

00:16:34.029 --> 00:16:36.950
day is ideal. You don't need more. You don't

00:16:36.950 --> 00:16:39.570
need less. Higher doses don't improve results.

00:16:39.850 --> 00:16:41.690
They typically just give you a stomach ache.

00:16:41.870 --> 00:16:44.990
Tip number three, timing matters less than you

00:16:44.990 --> 00:16:47.409
think. Doesn't matter when you take it. You can

00:16:47.409 --> 00:16:49.649
take it in the morning. You can take it at night.

00:16:49.769 --> 00:16:52.710
Take it when you'll remember. You could take

00:16:52.710 --> 00:16:55.490
it with or without food, pre or post workout.

00:16:55.980 --> 00:16:58.120
Difference is minimal. A lot of people take it

00:16:58.120 --> 00:17:01.620
post -workout, and I'll tell you why. Tip number

00:17:01.620 --> 00:17:04.759
four, pair it with carbs or protein. This is

00:17:04.759 --> 00:17:08.160
optional but can be helpful. Insulin helps shuttle

00:17:08.160 --> 00:17:10.599
creatine into the muscles. So taking creatine

00:17:10.599 --> 00:17:14.059
with a meal can slightly improve the uptake.

00:17:14.200 --> 00:17:17.500
It's not required, but it could be helpful. Number

00:17:17.500 --> 00:17:20.460
five, this one's huge. Give it time. It's not

00:17:20.460 --> 00:17:23.349
caffeine. The muscle benefits can take weeks.

00:17:23.390 --> 00:17:26.529
The brain benefits can take longer. Subtle improvements

00:17:26.529 --> 00:17:31.109
will show up over time with patience. Now, let's

00:17:31.109 --> 00:17:33.589
bring this home, guys. Creatine isn't a trend,

00:17:33.750 --> 00:17:36.730
a shortcut, or a gym gimmick, okay? It's one

00:17:36.730 --> 00:17:39.890
of the most researched compounds in human performance

00:17:39.890 --> 00:17:43.470
because it works at the most fundamental level,

00:17:43.549 --> 00:17:46.990
cellular energy. In muscle tissue, creatine helps

00:17:46.990 --> 00:17:50.170
regenerate ATP so you can train harder, recover

00:17:50.170 --> 00:17:53.700
faster, and preserve lean muscle mass. In the

00:17:53.700 --> 00:17:56.599
brain, it acts as an energy buffer, helping you

00:17:56.599 --> 00:17:59.420
stay mentally resilient during stress, fatigue,

00:17:59.799 --> 00:18:04.059
and aging. You don't need a loading phase. You

00:18:04.059 --> 00:18:06.819
don't need fancy forms. You don't need to cycle

00:18:06.819 --> 00:18:10.119
it. Just simple daily dose of creatine monohydrate

00:18:10.119 --> 00:18:14.259
taken consistently. Any early waking is water

00:18:14.259 --> 00:18:17.460
inside the muscles, not fat. The safety concerns

00:18:17.460 --> 00:18:20.339
you hear, they don't hold up, guys. No research

00:18:20.339 --> 00:18:22.779
on them. Creatine isn't about stimulation, it's

00:18:22.779 --> 00:18:25.640
about support. It doesn't push your body beyond

00:18:25.640 --> 00:18:28.339
its limits. It helps your cells do what they're

00:18:28.339 --> 00:18:30.819
already designed to do just more efficiently.

00:18:31.140 --> 00:18:34.640
So whether your goal is strength, recovery, focus,

00:18:34.779 --> 00:18:37.940
or long -term health, creatine definitely earns

00:18:37.940 --> 00:18:41.119
its place as a foundational supplement. Not because

00:18:41.119 --> 00:18:59.759
it's exciting, but because it's reliable. That's

00:18:59.759 --> 00:19:02.140
a wrap. Thanks for joining us today for another

00:19:02.140 --> 00:19:05.059
great episode. I hope you found this useful and

00:19:05.059 --> 00:19:06.900
look forward to helping you move forward in your

00:19:06.900 --> 00:19:09.039
continued pursuit of knowledge. It doesn't have

00:19:09.039 --> 00:19:11.480
to end here though. Check us out on TikTok, Facebook,

00:19:11.700 --> 00:19:14.099
and Instagram. If you want to be on an episode

00:19:14.099 --> 00:19:17.259
of Hormones Happen, shoot us a message at hormoneshappen

00:19:17.259 --> 00:19:22.279
at stillcity -trt .com. Stay hungry, stay optimized.
